GlyNAC is a nutritional supplement that combines glycine and N-acetylcysteine (NAC).
It is used to support glutathione production, oxidative balance, and cellular health.
GlyNAC has been studied primarily in the context of aging, metabolic health, and mitochondrial function. This page explains what GlyNAC is, how it works, potential benefits, dosage considerations, and safety based on available human research.
What Does GlyNAC Stand For?
GlyNAC stands for:
- Gly – glycine, a conditionally essential amino acid
- NAC – N-acetylcysteine, a cysteine precursor
Together, glycine and NAC provide the raw materials needed to produce glutathione, one of the body’s most important intracellular antioxidants.
How GlyNAC Works in the Body
Glutathione synthesis requires three amino acids:
- Glycine
- Cysteine
- Glutamate
In many adults, especially with aging, glycine and cysteine availability becomes limiting. GlyNAC supplementation aims to correct this limitation.
Proposed mechanisms include:
- Supporting intracellular glutathione levels
- Reducing oxidative stress
- Improving mitochondrial efficiency
- Supporting insulin sensitivity and metabolic pathways
These mechanisms are why GlyNAC is often discussed in aging and metabolic health research.
Potential Benefits of GlyNAC
Research and clinical interest around GlyNAC focuses on several areas:
- Cellular antioxidant support
- Mitochondrial function
- Metabolic health
- Inflammation balance
- Physical function in older adults
A detailed breakdown is available on the GlyNAC benefits page.
GlyNAC Dosage Overview
There is no single universal GlyNAC dose.
Clinical studies typically use combined daily doses of glycine and NAC, adjusted for body weight and study design. Supplement products may vary in:
- Glycine-to-NAC ratio
- Capsule vs powder form
- Total daily amount
For practical guidance, see the dedicated GlyNAC dosage page.
Is GlyNAC Safe?
Glycine and NAC are both widely studied compounds.
General safety considerations:
- Glycine is generally well tolerated
- NAC has a long history of medical and supplemental use
- Mild gastrointestinal effects are the most commonly reported side effects
People with medical conditions or those taking medications should consult a healthcare professional before starting GlyNAC.
A full safety discussion is available on the GlyNAC side effects and safety page.
GlyNAC vs Glutathione Supplements
Some people compare GlyNAC directly with glutathione supplements.
Key differences:
- GlyNAC supports endogenous glutathione production
- Oral glutathione has variable absorption
- GlyNAC targets precursor availability rather than direct replacement
A detailed comparison is covered in GlyNAC vs glutathione.
Who GlyNAC Is For
This site is intended for people who want:
- Evidence-based information
- Clear explanations without exaggerated claims
- Context from human research
The content is informational and does not replace professional medical advice.
Choosing a GlyNAC Supplement
If you are considering supplementation, product quality matters.
Important factors include:
- Transparent labeling
- Clear glycine and NAC dosages
- Third-party testing where available
See Best GlyNAC supplement for product comparisons and selection criteria.